Multiscale modelling of insulin secretion during an intravenous glucose tolerance test

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Multiscale modelling of insulin secretion during an intravenous glucose tolerance test.

Dysfunctional insulin secretion from pancreatic β-cells plays a major role in the development of diabetes. The intravenous glucose tolerance test (IVGTT) is a widely used clinical test to assess β-cell function. The analysis of IVGTT data is conveniently performed using mathematical models, which need to be fairly simple to enable parameter identifiability (minimal models), but should at the sa...

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ژورنال

عنوان ژورنال: Interface Focus

سال: 2013

ISSN: 2042-8898,2042-8901

DOI: 10.1098/rsfs.2012.0085